Description
FOXO4-DRI (Forkhead Box O4-D-Retro-Inverso) is a synthetic retro-inverso peptide composed entirely of D-amino acids. Engineered to target the interaction between endogenous FOXO4 and p53 proteins, this reagent possesses high proteolytic stability and excellent cell permeability.
In senescent cells, the binding of FOXO4 to p53 inhibits p53-mediated apoptosis, allowing senescent cells to persist and secrete pro-inflammatory factors. FOXO4-DRI competitively disrupts the FOXO4-p53 complex, thereby restoring the pro-apoptotic activity of p53. It selectively induces apoptosis in senescent cells with minimal impact on normal viable cells.
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